| Autor: |
Andersen, Morten N, Hønge, Bo L, Jespersen, Sanne, Medina, Candida, Té, David da Silva, Laursen, Alex, Wejse, Christian, Erikstrup, Christian, Møller, Holger J, Group, Bissau HIV Cohort Study, da Silva Té, David, Bissau HIV Cohort Study Group |
| Předmět: |
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| Zdroj: |
Journal of Infectious Diseases; 10/15/2018, Vol. 218 Issue 8, p1291-1295, 5p |
| Abstrakt: |
Macrophages play important roles during human immunodeficiency virus (HIV) infection, reflected by changes in macrophage-activation biomarker soluble CD163 (sCD163). Here, we present data on the novel macrophage-activation biomarker soluble mannose receptor/CD206 (sCD206) in HIV infection. We investigated sCD206 blood levels at baseline and follow-up with/without antiretroviral therapy (ART), in 212 patients with HIV type 1 (HIV-1), HIV type 2 (HIV-2), or dual infection. At baseline, there was no difference in sCD206 level between HIV types, and sCD206 was unchanged at follow-up without ART. However, in contrast to sCD163, sCD206 levels decreased significantly for both HIV-1 and HIV-2, but not for HIV-1/2 patients, during ART. Further investigations are needed to establish sCD206 as a biomarker in HIV infection. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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