| Autor: |
Kristensen, Nanna M., Hoyne, Gerard F., Hayball, John D., Hetzel, Charlotte, Bourne, Timothy, Lamb, Jonathan R. |
| Zdroj: |
International Immunology; Jul1996, Vol. 8 Issue 7, p1091-1098, 8p, 1 Chart, 5 Graphs |
| Abstrakt: |
In this study we demonstrate that immunization of H-2b mice with the allergen Der p 1 induces MHC class II restricted T cells that proliferate to residues 15–29 of Der p 1 (p15–29) and to the murine MHC class II-associated invariant chain derived peptide (CLIP). T cells from naive H-2b mice and those immunized with murine CLIP fail to respond to either CLIP or p15–29. T cell lines and clones reactive with p15–29 strongly proliferate in response to splenic antigen-presenting cells (APC) from normal H-2b mice but show reduced proliferation to APC from invariant chain deficient mice. Furthermore, T cells isolated from Der p 1 primed mice and expanded on H-2b spleen cells in the absence of the p15–29 epitope retained specificity for both p15–29 and CLIP, suggesting that naturally presented self components can act as mimetic peptides and may maintain T cell memory to foreign antigens. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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