| Autor: |
Bonfili, Laura, Cecarini, Valentina, Cuccioloni, Massimiliano, Angeletti, Mauro, Berardi, Sara, Scarpona, Silvia, Rossi, Giacomo, Eleuteri, Anna Maria |
| Zdroj: |
Molecular Neurobiology; Oct2018, Vol. 55 Issue 10, p7987-8000, 14p |
| Abstrakt: |
The gut-brain axis is a bidirectional communication network functionally linking the gut and the central nervous system (CNS). Based on this, the rational manipulation of intestinal microbiota represents a novel attractive therapeutic strategy for the treatment of CNS-associated disorders. In this study, we explored the properties of a probiotic formulation (namely SLAB51) in counteracting brain oxidative damages associated with Alzheimer’s disease (AD). Specifically, transgenic AD mice (3xTg-AD) were treated with SLAB51 and the effects on protein oxidation, neuronal antioxidant defence and repair systems were monitored, with the particular focus on the role of SIRT1-related pathways. We demonstrated that SLAB51 markedly reduced oxidative stress in AD mice brain by activating SIRT1-dependent mechanisms, thus representing a promising therapeutic adjuvant in AD treatment. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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