| Autor: |
Üstün, Sertaç, Ayyıldız, Nazife, Kale, Emre H., Çalışır, Öykü Mançe, Şenol, Pınar Uran, Öner, Özgür, Olkun, Sinan, Çiçek, Metehan |
| Předmět: |
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| Zdroj: |
Anatomy: International Journal of Experimental & Clinical Anatomy; May2018, Vol. 12 Issue Supp1, pS27-S28, 2p |
| Abstrakt: |
Objective: Dyscalculia is a learning disability affecting the acquisition of arithmetical skills in children with normal intelligence and age-appropriate education. Neural basis of dyscalculia is still unclear. In this study, number processing in children with dyscalculia and typically developing children were examined via functional magnetic resonance imaging (fMRI). Methods: Firstly, we tested 1944 third-grade students (7-9.5 years) in elementary schools with Mathematics-and-Arithmetic- Performance-Tests, and Raven-Progressive-Matrices-Test for intelligence. Secondly, children with low and normal mathematical performance was determined and tested two years later with mathematics tests, Weschler-Intelligence-Scale-for-Children, and evaluated by child-psychiatrist. After co-morbidities were eliminated, dyscalculia (n=12, mean age:11.25) and control (n=15, mean age:11.26) groups were identified. Participants were asked to perform a numerosity comparison paradigm while undergoing fMRI. Paradigm consists of two types of number condition and two difficulty levels. Imaging data was analyzed with repeated-measures ANOVA with group (dyscalculia/control), number (symbol/dot) and difficulty (0.5/0.7 ratio) as factors via MATLAB toolbox SPM12. Voxels presenting p<0.001 and belonging to clusters of at least 100 voxels were considered activated. Results: The main effect of number showed bilateral intraparietal sulcus (IPS), dorsolateral prefrontal cortex (DLPFC), supplementary motor area and occipitotemporal cortex activations. The main effect of difficulty activated bilateral insular cortex (IC), anterior cingulate cortex (AIC), IPS and right DLPFC. For the main effect of group orbitofrontal cortex was activated. There was no significant interaction effect. Conclusion: The frontoparietal network activation during number task is compatible with literature. IC and AIC activation were related to task difficulty in the previous reports. Higher frontal activity in dyscalculia group could be related to the requirement of more cognitive control, which might be the result of a deficiency of parietal brain regions related number sense mechanisms. This study was supported by TUBITAK under the project code 214S069. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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