Economic burden of HIV and TB/HIV coinfection in a middle-income country: a costing analysis alongside a pragmatic clinical trial in Brazil.

Autor: de Siqueira-Filha, Noemia Teixeira, de Fatima Militao de Albuquerque, Maria, Rodrigues, Laura Cunha, Legood, Rosa, Santos, Andreia Costa, Teixeira de Siqueira-Filha, Noemia, Militao de Albuquerque, Maria de Fatima, Cunha Rodrigues, Laura, Costa Santos, Andreia
Předmět:
Zdroj: Sexually Transmitted Infections; Sep2018, Vol. 94 Issue 6, p463-469, 7p, 4 Charts
Abstrakt: Objective: The objective of this study was to measure the costs of people living with HIV (PLHIV) as well as active tuberculosis (TB/HIV), latent tuberculosis infection (LTBI/HIV) or without TB (HIV/AIDS).Methods: We analysed the costs through the entire pathway of care during the prediagnosis and treatment periods from the Brazilian public health system perspective. We applied a combination of bottom-up and top-down approaches to capture and estimate direct medical and non-medical costs. We measured the mean cost per patient per type of care (inpatient, outpatient and emergency care) and disease category (HIV/AIDS, HIV/AIDS death, TB/HIV, TB/HIV death and LTBI/HIV).Results: Between March 2014 and March 2016 we recruited 239 PLHIV. During the follow-up 26 patients were diagnosed and treated for TB and 5 received chemoprophylaxis for LTBI. During the prediagnosis and treatment period, the mean total costs for HIV or AIDS and AIDS death categories were US$1558 and US$2828, respectively. The mean total costs for TB/HIV and TB/HIV death categories were US$5289.0 and US$8281, respectively. The mean total cost for the LTBI/HIV category was US$882.Conclusions: Patients with TB/HIV impose a higher economic burden on the health system than HIV/AIDS and LTBI/HIV. Patients with LTBI/HIV were the lowest cost group among all disease categories, indicating that preventive TB treatment can avoid the further costs treating active TB.Trial Registration Number: RBR-22t943, Results. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index