| Autor: |
Lee, Song Yi, Nam, Suyeong, Kim, Sungyun, Koo, Ja Seong, Hong, In Kee, Kim, Hill, Han, Sangin, Kang, Minji, Yang, Heejung, Cho, Hyun-Jong |
| Předmět: |
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| Zdroj: |
Evidence-based Complementary & Alternative Medicine (eCAM); 8/19/2018, Vol. 2018, p1-8, 8p, 2 Color Photographs, 1 Chart, 5 Graphs |
| Abstrakt: |
A cream formulation containing Artemisia capillaris (AC) extract (ACE) was developed for psoriasis therapy. Although ACE can be dissolved in organic solvents, its topical application is restricted because of toxicities. Therefore, a cream formulation was developed for the convenient and safe local application of ACE on skin lesions. The antipsoriatic properties of the ACE cream were evaluated using an imiquimod- (IMQ-) induced psoriasis-like mouse model. In psoriasis-like mouse models, the cumulative score (redness, thickness, and scaling) of the IMQ + ACE cream group was significantly lower than those of the other groups on day 4 (p < 0.05). The results of the hematoxylin and eosin staining of skin tissues revealed that the epidermal thickness value of the IMQ + ACE cream group was significantly lower than those of the other experimental groups (p < 0.05). The expression level of intracellular adhesion molecule-1 (ICAM-1), which indicates the leukocyte infiltration into the skin and subsequent interactions with keratinocytes, was also lower in the IMQ + ACE cream group than in the IMQ group. These results indicate that ACE cream formulation could be used safely and conveniently for psoriasis treatment. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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