| Autor: |
Millenet, Sabina K., Nees, Frauke, Heintz, Stefan, Bach, Christiane, Frank, Josef, Vollstädt-Klein, Sabine, Bokde, Arun, Bromberg, Uli, Büchel, Christian, Quinlan, Erin B., Desrivières, Sylvane, Fröhner, Juliane, Flor, Herta, Frouin, Vincent, Garavan, Hugh, Gowland, Penny, Heinz, Andreas, Ittermann, Bernd, Lemaire, Herve, Martinot, Jean-Luc |
| Předmět: |
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| Zdroj: |
Frontiers in Genetics; 7/31/2018, pN.PAG-N.PAG, 8p |
| Abstrakt: |
The dopaminergic system has been shown to have substantial effects on the etiology of attention-deficit hyperactivity disorder (ADHD). However, while some studies found a significant direct effect, others did not. In this context, social behavior might play an important role as a factor that is related both to the dopaminergic system and ADHD. In a large epidemiological sample of adolescents (N = 462; 16–17 years), we assessed the level of ADHD symptoms using the Strengths and Difficulties Questionnaire, social behavior using the Social Responsiveness Scale, and the allelic distribution of the dopaminergic catechol- O -methyltransferase (COMT) Val158Met polymorphism. We found a significant association between COMT and social impairment, insofar as Met-allele carriers showed increased levels of social impairment. Moreover, social impairment significantly determined an association between COMT and ADHD (explained variance: 19.09%). This effect did not significantly differ between males and females. COMT and social impairment might interactively affect ADHD symptomatology, and could thus represent significant gene-phenotypic risk factors for ADHD symptomatology. This might have interesting implications for prevention and intervention strategies with a focus on social behavior in genetically at-risk individuals. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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