| Autor: |
Haq, Aisha Abdul, Nigar, Soofia, Jabeen, Sarwat |
| Předmět: |
|
| Zdroj: |
Professional Medical Journal; 2018, Vol. 25 Issue 7, p1064-1068, 5p |
| Abstrakt: |
Objectives: To demonstrate the volume changes that are produced by anthracycline Doxorubicin DOX on the testes of mice and designed to study volumetric changes in DOX affected testes with co-administration of antioxidant Vitamin C. Design: An experimental study. Setting: Institute of Basic Medical Sciences. Dow University of Health Sciences. Period: September 2011 to May 2012. Methods: Experimental study using thirty male mice of five weeks old were separated into 3 groups (A, B & C). Each group had ten mice and was treated with normal saline 1 ml intraperitoneal (IP) in group A, DOX alone (0.003 mg in 0.03ml /gm body weight IP for 3 doses on 6th, 8th and 10th day of study) in group B and DOX (0.003 mg in 0.03ml /gm body weight IP for 3 doses on 6th, 8th and 10th day of study) + Vitamin C (0.5 mg in 0.01ml/gm body weight per orumdaily) in group C. After completion of study, animals were sacrificed and the testes were kept in Bouin's fluid and volume was measured. Results: By using SPSSS version 16, statistical analysis was done, using ANOVA test to evaluate the significance of concerned parameter among different groups studied. The administration of DOX induced significant reduction (P <0.001) of volume of testes when compared to controls. However co-administration of Vitamin C with DOX significantly increase (P <0.001) the volume as compared to DOX group. Conclusion: This study suggested that the antioxidant Vitamin C has a significant role in ameliorating the damage of testes induced by DOX, showing improvement in the morphology and morphometry of testes. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
