Low maternal vitamin D status in pregnancy increases the risk of childhood obesity.

Autor:	Roumeliotaki, T., Chalkiadaki, G., Karachaliou, M., Leventakou, V., Vafeiadi, M., Sarri, K., Daraki, V., Chatzi, L., Papavasiliou, S., Katrinaki, M., Vassilaki, M., Kogevinas, M.
Předmět:	RISK of childhood obesity ADIPOSE tissues BLOOD pressure CARDIOVASCULAR diseases risk factors CHILD health services CONFIDENCE intervals LIPIDS LONGITUDINAL method MULTIVARIATE analysis PRENATAL care REGRESSION analysis SKINFOLD thickness VITAMIN D BODY mass index WAIST circumference STATISTICAL models CHILDREN PREGNANCY
Zdroj:	Pediatric Obesity; Aug2018, Vol. 13 Issue 8, p467-475, 9p
Abstrakt:	Summary: Background: Vitamin D may modulate adipogenesis. However, limited studies have investigated the effect of maternal vitamin D during pregnancy on offspring adiposity or cardiometabolic parameters with inconclusive results. Objectives: The objective of this study is to examine the association of maternal 25(OH)‐vitamin D [25(OH)D] status with offspring obesity and cardiometabolic characteristics in 532 mother–child pairs from the prospective pregnancy cohort Rhea in Crete, Greece. Methods: Maternal 25(OH)D concentrations were measured at the first prenatal visit (mean: 14 weeks, SD: 4). Child outcomes included body mass index standard deviation score, waist circumference, skin‐fold thickness, blood pressure and serum lipids at ages 4 and 6 years. Body fat percentage was also measured at 6 years. Body mass index growth trajectories from birth to 6 years were estimated by mixed effects models with fractional polynomials of age. Adjusted associations were obtained via multivariable linear regression analyses. Results: About two‐thirds of participating mothers had 25(OH)D concentrations <50 nmol L−1. Offspring of women in the low 25(OH)D tertile (<37.7 nmol L−1) had higher body mass index standard deviation score (β 0.20, 95% CI: 0.03, 0.37), and waist circumference (β 0.87 95% CI: 0.12, 1.63) at preschool age, compared with the offspring of women with higher 25(OH)D measurements (≥37.7 nmol L−1), on covariate‐adjusted analyses. The observed relationships persisted at age 6 years. We found no association between maternal 25(OH)D concentrations and offspring blood pressure or serum lipids at both time points. Conclusions: Exposure to very low 25(OH)D concentrations in utero may increase childhood adiposity indices. Given that vitamin D is a modifiable risk factor, our findings may have important public health implications. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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