| Autor: |
Ma, Jinmin, Zhao, Fang, Su, Wei, Li, Qiongfang, Li, Jiandong, Ji, Jingkai, Deng, Yong, Zhou, Yang, Wang, Xinfa, Yang, Huanming, Saksena, Nitin K, Kristiansen, Karsten, Wang, Hui, Liu, Yingxia |
| Zdroj: |
Personalized Medicine (17410541); 6/29/2018, Vol. 15 Issue 4, p251-269, 19p |
| Abstrakt: |
Aim: Co-infection in HIV-1 patients with Mycobacterium tuberculosis poses considerable risk of developing the immune reconstitution inflammatory syndrome (IRIS), especially upon the initiation of antiretroviral therapy (ART). Methodology & results: For transcriptomic analysis, peripheral blood mononuclear cells’ whole gene expression was used from three patient groups: HIV+ (H), HIV-TB+ (HT), HIV-TB+ with IRIS (HTI). Pathway enrichment and functional analysis was performed before and after highly active ART. Genes in the interferon-stimulating and ZNF families maintained tight functional interaction and tilted the balance in favor of TB-IRIS. Discussion & conclusion: The functional impairment of interaction between ZNF genes and interferon-stimulated genes, along with higher expression of S100A8/S100A9 genes possibly forms the genomic basis of TB-IRIS in a subset of HIV patients while on highly active ART. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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