H1N1pdm09 Influenza Virus and Its Descendants Lack Extra-epitopic Amino Acid Residues Associated With Reduced Recognition by M158-66-Specific CD8+ T Cells.

Autor:	Sandt, Carolien E van de, Sagong, Kyung A, Pronk, Mark R, Bestebroer, Theo M, Spronken, Monique I, Koopmans, Marion P G, Fouchier, Ron A M, Rimmelzwaan, Guus F, van de Sandt, Carolien E
Předmět:	AVIAN influenza A virus HEMAGGLUTININ AMINO acids T cells NUCLEOPROTEINS ANTIGENS COMPARATIVE studies INFLUENZA RESEARCH methodology MEDICAL cooperation GENETIC mutation PROTEINS RESEARCH EVALUATION research INFLUENZA A virus H1N1 subtype
Zdroj:	Journal of Infectious Diseases; 8/15/2018, Vol. 218 Issue 4, p581-585, 5p
Abstrakt:	Extra-epitopic amino acid residues affect recognition of human influenza A viruses (IAVs) by CD8+ T-lymphocytes (CTLs) specific for the highly conserved HLA-A*0201 restricted M158-66 epitope located in the matrix 1 (M1) protein. These residues are absent in the M1 protein of the 2009-pandemic IAV (H1N1pdm09). Consequently, stimulation with M1 protein of H1N1pdm09 IAV resulted in stronger activation and lytic activity of M158-66-specific CTLs than stimulation with seasonal H3N2 IAVs. During >6 years of circulation in the human population, descendants of the H1N1pdm09 virus had accumulated 4 other amino acid substitutions. However, these did not affect M158-66-specific CTL activation. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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