| Autor: |
Бъчваров, К., Аврамова, Б., Константинов, Д., Свинаров, Д., Савов, А., Андонова, С. |
| Zdroj: |
Pediatria; 2018, Vol. 58 Issue 1, p4-27, 4p |
| Abstrakt: |
While thiopurine antimetabolites are drugs, widely used in treating a variety of acute conditions, they also have a relativelynarrow therapeutic range. Their dosage is specifically tailored to the nosological unit and adapted with consideration to the specific tolerance as needed. Pharmacogenetic specificity is one of the main factors that predetermine treatment effectiveness. Thiopurine-S-Methyltransferase (TPMT) is a genetically polymorphic enzyme that catabolises them. Routine TPMT genotype monitoring ensures that they are properly dosed. Implementing it would have the benefit of being pharmacoeconomically cost-effective. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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