| Abstrakt: |
The effect of xymedon hydrochloride on the immune response of rabbits immunized with the rabies vaccine prepared from strain Shchelkovo-51 under the influence of immunosupression induced by cyclophosphamide has been studied. Xymedon hydrochloride was injected at a dose of 5 mg kg body weight in a volume of 1 cm3 twice a day in combination with the rabies vaccine. In addition, the immune response higher level of 1: 12800 was observed in the immunosupressed animals compared to 1: 6400 in the control animals immunized without the immunostimulant. At 6 months after vaccination, the antibody concentration of 1: 93.75 ± 44.68 remaining below the protective level was recorded, which indicated the weakness of the humoral link in the immune system. The counts of T- lymphocytes, B-lymphocytes, T-helpers, and T-suppressors in the blood of the immunesuppressed rabbits immunized with the rabies vaccine in combination with xymedon hydrochloride increased 3.2-fold, 1.9-fold, 7.7-fold, and 22.0-fold, respectively, when compared with the reference values. Therefore, the protective effect was followed by increasing the antigeninduced and spontaneuous lymphocyte proliferation, the numbers of T-helper cells and T lymphocytes exhibiting the cytotoxic and suppressive activity, and the virus-specific neutralizing antibody titers in cases wherein the Shchelkovo-51 vaccine in combination with xymedon hydrochloride was administered. It should be reasonable to apply the two-step rabies vaccination with the use of the immunostimulant, in particular, xymedon hydrochloride, to ensure the adequate immune response in immunodeficient animals. [ABSTRACT FROM AUTHOR] |
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