Autor: |
Yang, Fang, Han, Huaxin, Fan, Hongxian, Xiao, Dan, Chen, Yuhuan, Li, Gang |
Předmět: |
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Zdroj: |
Colloid & Polymer Science; Aug2018, Vol. 296 Issue 8, p1401-1407, 7p |
Abstrakt: |
A novel drug carrier was synthesized through grafting polymerization of water-insoluble glucan from cotton cellulose tailored and polyoxyethylene oxide (PEO). By changing the molar ratio of water-insoluble glucan and ethylene oxide (EO), glucan-g-PEO copolymers with different chain lengths of PEO can be obtained. The physicochemical characteristics of docetaxel (DTX)-loaded glucan-g-PEO such as micro-morphology, size, critical micelle concentration (CMC), and in vitro release of kinetic were investigated. In vitro release profiles of docetaxel (DTX)-loaded glucan-g-PEO meet first-order release kinetics via a mechanism of diffusion and polymer chain relaxation. Another significant result is that release rates of DTX can be also modulated by changing the chain lengths of the PEO segments. [ABSTRACT FROM AUTHOR] |
Databáze: |
Complementary Index |
Externí odkaz: |
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