Synthesis, characterization, and in vitro release analysis of a novel glucan-based polymer carrier.

Autor:	Yang, Fang, Han, Huaxin, Fan, Hongxian, Xiao, Dan, Chen, Yuhuan, Li, Gang
Předmět:	GLUCANS POLYMERIZATION DRUG carriers CELLULOSE POLYETHYLENE glycol
Zdroj:	Colloid & Polymer Science; Aug2018, Vol. 296 Issue 8, p1401-1407, 7p
Abstrakt:	A novel drug carrier was synthesized through grafting polymerization of water-insoluble glucan from cotton cellulose tailored and polyoxyethylene oxide (PEO). By changing the molar ratio of water-insoluble glucan and ethylene oxide (EO), glucan-g-PEO copolymers with different chain lengths of PEO can be obtained. The physicochemical characteristics of docetaxel (DTX)-loaded glucan-g-PEO such as micro-morphology, size, critical micelle concentration (CMC), and in vitro release of kinetic were investigated. In vitro release profiles of docetaxel (DTX)-loaded glucan-g-PEO meet first-order release kinetics via a mechanism of diffusion and polymer chain relaxation. Another significant result is that release rates of DTX can be also modulated by changing the chain lengths of the PEO segments. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
Externí odkaz:	Zobrazit plný text záznamu Full text from SpringerLink