Sagittal abdominal diameter resembles waist circumference as a surrogate marker of insulin resistance in adolescents—Brazilian Metabolic Syndrome Study.
| Autor: | da Silva, Cleliani de Cassia, Vasques, Ana Carolina J., Zambon, Mariana P., Camilo, Daniella F., De Bernardi Rodrigues, Ana Maria, Antonio, Maria Ângela R. G. M., Geloneze, Bruno, On Behalf of the Brazilian Metabolic Syndrome Study (BRAMS) Investigators |
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| Předmět: |
HYPERGLYCEMIA
METABOLIC syndrome diagnosis AGE distribution BIOMARKERS BLOOD pressure BODY size HIGH density lipoproteins HOMEOSTASIS INSULIN resistance MEDICAL cooperation MULTIVARIATE analysis REGRESSION analysis RESEARCH SEX distribution TRIGLYCERIDES URIC acid CROSS-sectional method WAIST circumference GLUCOSE clamp technique ADOLESCENCE DIAGNOSIS |
| Zdroj: | Pediatric Diabetes; Aug2018, Vol. 19 Issue 5, p882-891, 10p, 3 Charts, 3 Graphs |
| Abstrakt: | Objective: To evaluate the association of the sagittal abdominal diameter (SAD) with insulin resistance (IR) and metabolic syndrome (MetS) components, and to compare SAD with waist circumference (WC). Subjects/Methods: This was a multicenter, cross‐sectional study of 520 adolescents (10‐ to 18‐years old). IR was assessed using the homeostasis model assessment of IR (HOMA‐IR) and the hyperglycaemic clamp (n = 76). Results: SAD and WC were positively correlated with HOMA‐IR (r = 0.637 and r = 0.653) and inversely correlated with the clamp‐derived insulin sensitivity index (ISI) (r = −0.734 and r = −0.731); P < .001. In the multivariable linear regression analysis, SAD was positively associated with HOMA‐IR (B = 0.046 ± 0.003) and inversely associated with the clamp‐derived ISI (B = −0.084 ± 0.009) after adjusting for sex, age, and Tanner's stages (P < .001). When WC replaced the SAD, it was positively associated with HOMA‐IR (B = 0.011 ± 0.001) and inversely associated with the clamp‐derived ISI (B = −0.018 ± 0.002); P < .001. The values of the areas under the curves (AUC) were 0.823 and 0.813 for SAD and WC, respectively. In Bland‐Altman analysis, there were agreement between both, SAD and WC, with the clamp‐derived ISI (mean = 0.00; P > .05). The SAD and WC were positively associated with blood pressure, triglycerides, and uric acid, and inversely associated with high‐density lipoprotein (HDL)‐cholesterol after adjusting for sex, age, and Tanner's stages. Conclusion: The SAD was associated with IR and MetS components, with a good discriminatory power for detecting IR. When compared to WC, SAD showed equivalent results. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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