| Autor: |
Kong, Shun Yin, Lam, Wing Kit, Li, Ka Shu, Yeung, Ka Pik, Ha, Chung Yin, Lai, Ho Kei, Chan, Hay Nun, Yeung, Yiu Ming, Yip, Sze Fai |
| Předmět: |
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| Zdroj: |
Molecular & Clinical Oncology; 2018, Vol. 8 Issue 6, p757-759, 3p |
| Abstrakt: |
t(11;14) translocation is one of the most common chromosomal abnormalities in plasma cell myeloma. The present case report presented a case of plasma cell myeloma with t(11;14) translocation, in which the plasma cells were small lymphoplasmacytoids in morphology with positive cluster of differentiation-20 and Cyclin D1 expression. These results led to initial diagnostic difficulties. The patient was refractory to bortezomib-based therapy, and responsive to vincristine, doxorubicin and dexamethasone. However, the prognostic value of t(11;14) in plasma cell myeloma remains to be determined. With recent advances in treatment options, physicians should be aware of the clinical and pathological characteristics of this translocation in plasma cell myeloma. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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