Functional Graphene Oxide-Based Nanosheets for Photothermal Therapy.

Autor: Lim, Jae Hyun, Kim, Da Eun, Kim, Eun-Joong, Ahrberg, Christian D., Chung, Bong Geun
Zdroj: Macromolecular Research; Jun2018, Vol. 26 Issue 6, p557-565, 9p
Abstrakt: Cancer is one of the main causes of morbidity and mortality. Although a number of techniques are available for treatment, these methods still have a number of drawbacks, destroying healthy tissues and cells to cause various side effects. Here we present the synthesis and biological application of a composite nanomaterial, folic acid (FA)-conjugated graphene oxide (GO) nanosheets functionalized with manganese dioxide (MnO2) nanoparticles. While FA-conjugated GO nanosheets can be used for targeted photothermal therapy (PTT) when irradiated with a near infrared (NIR) light, MnO2 nanoparticles degrade hydrogen peroxide (H2O2) in the cancer microenvironment, countering hypoxia. Further the nanoparticles can be used as a contrast agent in MRI imaging. We demonstrated that MnO2-FA-GO nanosheets were uptaken by HeLa cells overexpressing FA receptors to induce NIR irradiation-mediated hyperthermia (35% viability). Therefore, this composite MnO2-FA-GO nanosheet could be a powerful carrier for cancer targeting and PTT applications. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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