| Autor: |
Zarzavadjian Le Bian, Alban, Denet, Christine, Tabchouri, Nicolas, Donatelli, Gianfranco, Wind, Philippe, Louvet, Christophe, Bennamoun, Mostefa, Christidis, Christos, Perniceni, Thierry, Fuks, David, Gayet, Brice |
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| Zdroj: |
Langenbeck's Archives of Surgery; Jun2018, Vol. 403 Issue 4, p443-450, 8p |
| Abstrakt: |
Purpose: Although association between colorectal cancer (CRC) and metabolic syndrome (MetS) is established, specific features of CRC arising in patients presenting with MetS have not been clearly identified.Method: All patients who underwent colectomy for CRC from January 2005 to December 2014 at Institut Mutualiste Montsouris were identified from a prospectively collected database and characteristics were compared in the entire population and in a 1:2 matched case-control analysis [variables on which matching was performed were CRC localization (right- or left-sided) and AJCC stage (0 to IV)].Results: Out of the 772 identified patients, 98 (12.7%) presented with MetS. Entire population analysis revealed that CRC associated with MetS was more frequent in men (71.4 vs. 47.8%, p < 0.001), more often right-sided (71.4 vs. 50.4%, p < 0.001) and presented with less synchronous liver metastasis (4.1 vs. 8.7%, p = 0.002). Case-control analysis confirmed the gender association (p < 0.001) and showed HNPCC (p < 0.001) and history family of CRC (p = 0.010) to be significantly more frequent in Non-MetS patients.Conclusions: CRC associated with MetS is more frequent in men, more often right-sided, and presents with fewer synchronous metastasis. Further investigations should be designed in order to confirm these results and to enhance our knowledge of carcinogenesis related to MetS. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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