New Ionic Conjugates Based on α-Tocopheryl Succinate as Potential Cytotoxic Agents.

Autor:	Frolova, T. S., Sharapov, S. Z., Sinitsyna, O. I., Tolstikova, T. G., Grigoriev, I. A., Morozov, S. V., Yushkova, Y. V.
Předmět:	SUCCINATES ANTINEOPLASTIC agents AMANTADINE CHEMICAL synthesis RIMANTADINE ANTIOXIDANTS
Zdroj:	Russian Journal of Bioorganic Chemistry; May2018, Vol. 44 Issue 3, p330-336, 7p
Abstrakt:	Five new ionic conjugates based on α-tocopheryl succinate were synthesized, including amino- TEMPO, cytisine, convolvin, amantadine, and rimantadine as functional groups. Using bacterial test systems, the safety of the compounds obtained was shown, and antioxidant properties were studied. Investigation of the cytotoxic properties of synthesized conjugates with a chromane skeleton revealed their selectivity to the MCF7 breast cancer line, the effect was most pronounced for derivatives with amino-TEMPO and rimantadine fragments. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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