Reactions of secondary propargylamines with heteroallenes for the synthesis of diverse heterocycles.

Autor: Peshkov, Vsevolod A., Pereshivko, Olga P., Nechaev, Anton A., Peshkov, Anatoly A., Van der Eycken, Erik V.
Předmět:
Zdroj: Chemical Society Reviews; 6/7/2018, Vol. 47 Issue 11, p3861-3898, 38p
Abstrakt: This focused review aims to summarize recent developments in the processes involving additions of secondary propargylamines to various heteroallenes and subsequent transition metal-catalyzed or electrophile-mediated cyclizations. The utility of this convenient and tunable strategy spans from the carbon dioxide fixation and target-oriented synthesis of complex natural and biologically active products to the generation of extended synthetic libraries of diverse oxygen-, nitrogen- and sulfur-containing heterocycles. For comparative purposes, the analogous transformations of propargylic alcohols are also highlighted in this account. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index