Sequential Au/Cu Catalysis: A Two Catalyst One‐Pot Protocol for the Enantioselective Synthesis of Oxazole α‐Hydroxy Esters via Intramolecular Cyclization/Intermolecular Alder‐Ene Reaction.

Autor:	Nalivela, Kumara Swamy, Rudolph, Matthias, Baeissa, Elham S., Alhogbi, Basma G., Mkhalid, Ibraheem A. I., Hashmi, A. Stephen K.
Předmět:	CATALYSTS ESTERS OXAZOLES RING formation (Chemistry) REGIOSELECTIVITY (Chemistry)
Zdroj:	Advanced Synthesis & Catalysis; 6/5/2018, Vol. 360 Issue 11, p2183-2190, 8p
Abstrakt:	Abstract: A convenient protocol for the enantioselective synthesis of oxazole α‐hydroxy ester derivatives 4 from readily available propargylamides 1 and alkylglyoxylates 3 was developed. The first step of the one‐pot procedure is the selective intramolecular in situ formation of an alkylideneoxazoline 2, which then in an intermolecular reaction is enantioselectively transformed to the oxazole α‐hydroxy ester derivatives 4 in quantitative yield and good to excellent enantioselectivity via an asymmetric copper(II)‐catalyzed Alder‐ene reaction. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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