| Autor: |
Dammermann, Werner, Mihajlov, Valentin, Middendorf, Barbara, Mellmann, Alexander, Karch, Helge, Lüth, Stefan, Ullrich, Sebastian |
| Předmět: |
|
| Zdroj: |
Journal of Gastroenterology & Hepatology; Jul2018, Vol. 33 Issue 7, p1353-1356, 4p, 1 Chart, 1 Graph |
| Abstrakt: |
Abstract: Background and Aim: An outbreak of Shiga toxin 2 (Stx2) producing enterohemorrhagic and enteroaggregative Escherichia coli O104:H4 infection in May 2011 in Germany caused enterocolitis and an unprecedented high 22% rate of hemolytic uremic syndrome (HUS). We hypothesized that anti‐Stx2 IgM or IgG titers might predict HUS development. Methods: Thirty‐two patients infected with enterohemorrhagic Escherichia coli O104:H4 (HUS: n = 23; non‐HUS: n = 9) were retrospectively screened for anti‐Stx2 IgM/IgG and matched with clinical data regarding HUS development, fever, superinfection, dialysis, neurological symptoms, intensive care, antibiotic treatment, and plasmapheresis. Results: Only HUS patients showed a prominent Stx2‐specific humoral response in the early acute phase. Despite a strong trend towards prediction of HUS development, statistical analysis revealed no significant correlation between high IgM/IgG titers and further key clinical parameters such as fever, superinfection, neurological symptoms, antibiotic treatment, and plasmapheresis. Conclusions: Anti‐Stx2 antibodies seem to accompany or even precede HUS development. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
Plný text