| Autor: |
Londen, Marco van, Wijninga, Anthony B, Vries, Jannieta de, Sanders, Jan-Stephan F, Jong, Margriet F C de, Pol, Robert A, Berger, Stefan P, Navis, Gerjan, Borst, Martin H de |
| Předmět: |
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| Zdroj: |
Nephrology Dialysis Transplantation; Jun2018, Vol. 33 Issue 6, p1054-1064, 11p, 6 Charts, 4 Graphs |
| Abstrakt: |
Background. Living kidney donor safety requires reliable longterm follow-up of renal function after donation. The current study aimed to define the precision and accuracy of postdonation estimated glomerular filtration rate (eGFR) slopes compared with measured GFR (mGFR) slopes. Methods. In 349 donors (age 51±10, 54% female), we analysed eGFR according to the 2009 Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation, Modification of Diet in Renal Disease (MDRD) and Cockcroft-Gault/body surface area (CG/BSA), creatinine clearance (CrCl) and mGFR (125I-iothalamate) changes from 3 months until 5 years postdonation. Results. Donors had a pre-donation mGFR of 116±23 mL/min, at 3 months post-donation mGFR was 73 ± 14 mL/min and at 5 years it was 79±16 mL/min. Between 3 months and 5 years post-donation, 28% of donors had a declining mGFR (-0.82±0.79 mL/min/year), 47% were stable and 25% had an increasing mGFR. Overall, eGFR equations showed good slope estimates (bias eGFRCKD-EPI 0.13±2.16 mL/min/year, eGFRMDRD 0.19±2.10 mL/min/year, eGFRCG/BSA -0.08±2.06 mL/min/year, CrCl -0.12±4.75 mL/min/year), but in donors with a decreasing mGFR the slope was underestimated (bias eGFRCKD-EPI 1.41±2.03 mL/min/year, eGFRMDRD 1.51±1.96 mL/min/year, eGFRCG/BSA 1.20±1.87 mL/min/year). Conclusions. All eGFR equations underestimated GFR slopes in donors with a declining GFR between 3 months and 5 years post-donation. This study underlines the value of mGFR in the follow-up of donors with risk of progressive GFR loss. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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