| Autor: |
Bhojan, Chitra, Sukumaran Nair, Manjula Devi Ananda Vally, Ravi, Thengungal Kochupappy |
| Předmět: |
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| Zdroj: |
International Journal of Chemical & Pharmaceutical Analysis; Oct-Dec2016, Vol. 4 Issue 1, p1-7, 7p |
| Abstrakt: |
UV spectrophotometric and chromatographic methods which are simple, accurate and precise have been developed and validated for the determination of Loxapine in its pharmaceutical formulation. The UV spectroscopic analysis was performed using water as solvent and detection was done at 297 nm. The HPTLC method was performed using Pre-coated silica gel G60 F254 plate using the mobile phase chloroform and methanol in the ratio of 9.5:0.5 v/v/v followed by analysis at 297 nm. Linearity was found over the concentration range of 10-80 μg/ml for UV method and 2 - 12 ng/spot for HPTLC method with correlation coefficient 0.9991 and 0.9933 respectively. Repeatability, Intraday and Interday studies shows % RSD less than 2, which indicates the precision of the developed method. The developed methods are more sensitive and cost effective. As no methods were developed for Loxapine by UV and HPTLC techniques they can be routinely used for the determination Loxapine in formulations. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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