DEVELOPMENT AND VALIDATION OF UV-VISIBLE SPECTROPHOTOMETRIC METHOD OF ESTIMATION OF TERBUTALIN SULPHATE IN BULK DRUG USING NINHYDRIN.

Autor: Vaishnav, Gajanan A., Vaishnav-Hota, Sushama, Godse, Shital, S. S., Angadi, S. J., Patil
Předmět:
Zdroj: International Journal of Chemical & Pharmaceutical Analysis; Oct-Dec2016, Vol. 4 Issue 1, p1-7, 7p
Abstrakt: An accurate, precise and simple spectrophotometric method for the determination of Terbutalin sulphate based on the formation of a yellow color product with Ninhydrin in the presence of sodium bicarbonate with an λmax at 346 nm. The Reaction heating temperature was 80°C for 30 min. The calibration curve was linear over the range of 10-60 μg/ml and the regression equation obtained was y=0.0263x+0.2 with a regression coefficient (r) of 0.98 (n=10). The limit of Detection (LOD) and limit of Quantification (LOQ) calculated as per ICH guidelines were 18.15μg/ml and 55μg/ml, respectively. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index