| Autor: |
Duarte, Fernando B., Barbosa, Maritza C., Jesus dos Santos, Talyta E., Lemes, Romélia P. G., Vasconcelos, João P., Vasconcelos, Paulo R. L., Rocha, Francisco D., Zalcberg, Ilana, Coutinho, Diego F. |
| Předmět: |
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| Zdroj: |
British Journal of Haematology; May2018, Vol. 181 Issue 4, p547-549, 3p |
| Abstrakt: |
The article discusses findings of a study on bone marrow fibrosis associated with TP53 gene overexpression and its role in prognosis in low-risk myelodysplastic syndrome. It states that immunohistochemical expression of TP53 has been used as a predictive marker for mutations in the TP53 gene, and mentions that patients with medullary fibrosis at diagnosis may develop an unfavorable clinical course. It notes that patients with the fibrosis and high TP53 expression had lower survival. |
| Databáze: |
Complementary Index |
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