| Autor: |
Wen-Li Qiao, Ling-Yan Shao, Ya-Hua Hu, Li-Hao Xing, Ke-Zuan Deng, Hong-Wei Liu, Dao-Hua Liao, Ya-Fei Ji |
| Předmět: |
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| Zdroj: |
Synlett; 2018, Vol. 29 Issue 9, p1249-1255, 7p |
| Abstrakt: |
A palladium-catalyzed Csp³-H bond mono-aroyloxylation of O-alkyl substituted oxime ethers has been developed by using 2,4,6-trimethoxybenzaldoxime as an exo-type directing group with exclusive site-selectivity. With the wide range of masked aliphatic alcohol substrates and aromatic acid coupling partners, the protocol allows rapid access to various 2-alkyl substituted glycol derivatives in synthetically useful to good yields. The employed directing group is readily removed, accordingly affording valuable functionalized aliphatic alcohols. When the solvent from hybrid DCE/HFIP to CH3CN, non-directed oxidative cross-coupling is observed between the electron-rich aromatic ring of substrates and aromatic acid partners. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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