Highly hindered 2-(aryl-di-tert-butylsilyl)-N-methyl-imidazoles: a new tool for the aqueous 19F- and 18F-fluorination of biomolecule-based structures.

Autor: Tisseraud, Marion, Schulz, Jürgen, Vimont, Delphine, Berlande, Murielle, Fernandez, Philippe, Hermange, Philippe, Fouquet, Eric
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Zdroj: Chemical Communications; 5/18/2018, Vol. 54 Issue 40, p5098-5101, 4p
Abstrakt: A new class of silicon-based fluoride acceptors with a C-linked heterocycle as the leaving group was synthesized in one step from commercial chemicals, and linked to biomolecules. The resulting conjugates were efficiently 19F-fluorinated in aqueous mixtures, and switching to 18F-labelling provided nucleoside- and peptide-based bioconjugates with excellent molar activities suitable for biological applications. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index