| Autor: |
Hofman, Gert-Jan, Ottoy, Emile, Light, Mark E., Kieffer, Bruno, Kuprov, Ilya, Martins, Jose C., Sinnaeve, Davy, Linclau, Bruno |
| Předmět: |
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| Zdroj: |
Chemical Communications; 5/18/2018, Vol. 54 Issue 40, p5118-5121, 4p |
| Abstrakt: |
Monofluorination at the proline 4-position results in conformational effects, which is exploited for a range of applications. However, this conformational distortion is a hindrance when the natural proline conformation is important. Here we introduce (3S,4R)-3,4-difluoroproline, in which the individual fluorine atoms instil opposite conformational effects, as a suitable probe for fluorine NMR studies. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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