| Autor: |
Ferrari, F., Vagnarelli, F., Gargano, G., Roversi, M. F., Biagioni, O., Ranzi, A., Cavazzuti, G. B. |
| Předmět: |
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| Zdroj: |
Archives of Disease in Childhood -- Fetal & Neonatal Edition; Jul2001, Vol. 85 Issue 1, pF66-F72, 7p, 2 Black and White Photographs, 2 Charts |
| Abstrakt: |
Objectives-To determine the incidence of catheter related thrombosis and to test the efficacy of recombinant tissue type plasminogen activator (rt-PA) in preterm infants. Study design-From January 1995 to December 1998, echocardiography was performed in the first few days of life in 76 very low birthweight (⩽ 1500 g) infants out of a total of 147 having an umbilical catheter placed. When intracardiac thrombosis was diagnosed, rt-PA infusion was per- formed. Results-Four infants (5%) developed an intracardiac thrombosis during the first few days of life. In three of them, rt-PA at a dose of 0.4-0.5 mg/kg in a 20-30 minute bolus led to dissolution of the clot. One patient received a three hour infusion after the bolus, at a dose of 0.1 mg/kg/h, with resolution of the thrombus. No systemic effects were observed after rt-PA infusion. Conclusions-Early thrombosis may occur as a complication of umbilical catheterisation in preterm infants; early echocardiographic detection of this disorder allows complete, safe, and rapid lysis with rt-PA. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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