| Autor: |
Chen, S. H. A., Kareken, D. A., Fastenau, P. S., Trexler, L. E., Hutchins, G. D. |
| Předmět: |
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| Zdroj: |
Journal of Neurology, Neurosurgery & Psychiatry; Mar2003, Vol. 74 Issue 3, p326-332, 7p, 1 Color Photograph, 1 Diagram, 3 Charts, 1 Graph |
| Abstrakt: |
Background: Complaints of persistent cognitive deficits following mild head trauma are often uncorroborated by structural brain imaging and neuropsychological examination.Objective: To investigate, using positron emission tomography (PET), the in vivo changes in regional cerebral uptake of 2-[(18)F]fluoro-2-deoxy-D-glucose (FDG) and regional cerebral blood flow (rCBF) in patients with persistent symptoms following mild head trauma.Methods: Five patients with mild head trauma and five age and education matched healthy controls were imaged using FDG-PET to measure differences in resting regional cerebral glucose metabolism. Oxygen-15 labelled water (H(2)(15)O)-PET was also used to measure group differences in rCBF changes during a spatial working memory task. In addition, neuropsychological testing and self report of dysexecutive function and post-concussion symptoms were acquired to characterise the sample.Results: There was no difference between patients and controls in normalised regional cerebral FDG uptake in the resting state in frontal and temporal regions selected a priori. However, during the spatial working memory task, patients had a smaller increase in rCBF than controls in the right prefrontal cortex.Conclusions: Persistent post-concussive symptoms may not be associated with resting state hypometabolism. A cognitive challenge may be necessary to detect cerebral changes associated with mild head trauma. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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