| Autor: |
Rosenman, David J., Clemente, Nicolina, Ali, Muhammad, García, Angel E., Wang, Chunyu |
| Předmět: |
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| Zdroj: |
Chemical Communications; 5/4/2018, Vol. 54 Issue 36, p4609-4612, 4p |
| Abstrakt: |
Here we present the high pressure NMR characterization of Aβ42 and two Aβ40 variants with Alzheimer-causing mutations E22G and D23N. While chemical shifts only identified localized changes at ambient pressure compared with Aβ40, high pressure NMR revealed a common site with heightened pressure sensitivity at Q15, K16 and L17 in all three variants, which correlates to higher β-propensity at central hydrophobic cluster (CHC) and faster aggregation. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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