| Autor: |
de Mesy Bentley, Karen L., MacDonald, Ashlee, Schwarz, Edward M., Oh, Irvin |
| Předmět: |
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| Zdroj: |
JBJS Case Connector; Jan-Mar2018, Vol. 8 Issue 1, p1-4, 4p |
| Abstrakt: |
Case: A patient presenting with an infected diabetic foot ulcer and Staphylococcus aureus chronic osteomyelitis was studied to validate the clinical importance of bacterial colonization of osteocytic-canalicular networks, as we recently reported in a mouse model. We utilized transmission electron microscopy to describe the deformation of S. aureus, from round cocci to rod-shaped bacteria, in the submicron osteocytic-canalicular networks of amputated bone tissue. Conclusion: To our knowledge, this is the first evidence of S. aureus deformation and invasion of the osteocyticcanalicular system in human bone, which supports a new mechanism of persistence in the pathogenesis of chronic osteomyelitis. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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