Comparison of Aspirin and Naoxintong Capsule (脑心通胶囊) with Adjusted-Dose Warfarin in Elderly Patients with High-Risk of Non-Valvular Atrial Fibrillation and Genetic Variants of Vitamin K Epoxide Reductase.
Autor: | Wang, Huan, Zhou, Xiao-kai, Zheng, Li-fan, Wu, Xiao-ying, Chen, Hui |
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Předmět: |
STROKE-related mortality
ASPIRIN ATRIAL fibrillation COMBINATION drug therapy COMPARATIVE studies CONFIDENCE intervals GENETIC polymorphisms HEMORRHAGE ISCHEMIA CHINESE medicine ORAL drug administration OXIDOREDUCTASES STROKE THROMBOEMBOLISM WARFARIN RANDOMIZED controlled trials TREATMENT effectiveness INTERNATIONAL normalized ratio ODDS ratio GENOTYPES DISEASE complications OLD age GENETICS |
Zdroj: | Chinese Journal of Integrative Medicine; Apr2018, Vol. 24 Issue 4, p247-253, 7p |
Abstrakt: | Objective: To compared the therapeutic effect of a Chinese patent medicine Naoxintong Capsule (脑心通胶囊, NXT) and aspirin with adjusted-dose warfarin in Chinese elderly patients (over 65 years) with nonvalvular atrial fibrillation (NVAF) and genetic variants of vitamin K epoxide reductase (VKORC1), who are at high-risk of thromboembolism.Methods: A total of 151 patients, with NVAF and AA genotype of VKORC1-1639 (a sensitive genotype to warfarin) and a CHA |
Databáze: | Complementary Index |
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