[18F]fluoro-benziodoxole: a no-carrier-added electrophilic fluorinating reagent. Rapid, simple radiosynthesis, purification and application for fluorine-18 labelling.

Autor: Cortés González, Miguel A., Nordeman, Patrik, Bermejo Gómez, Antonio, Meyer, Denise N., Antoni, Gunnar, Schou, Magnus, Szabó, Kálmán J.
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Zdroj: Chemical Communications; 4/25/2018, Vol. 54 Issue 34, p4286-4289, 4p
Abstrakt: Operationally simple radiosynthesis and purification of [18F]fluoro-benziodoxole was developed starting from a cyclotron produced [18F]F precursor, [18F]TBAF, and tosyl-benziodoxole. The synthetic utility of [18F]fluoro-benziodoxole was demonstrated by electrophilic fluorocyclization of o-styrilamides proceeding with high RCC (typically 50–90%) and high molar activity (up to 396 GBq μmol−1). [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index