Comparison of maternal omentin-1 levels and genetic variability between spontaneous term and preterm births.

Autor: Šplíchal, Zbyněk, Zlámal, Filip, Máchal, Jan, Lipková, Jolana, Pavlová, Tereza, Hodická, Zuzana, Ventruba, Pavel, Vašků, Anna, Bienertová-Vašků, Julie
Předmět:
Zdroj: Journal of Maternal-Fetal & Neonatal Medicine; Jul2018, Vol. 31 Issue 13, p1689-1695, 7p
Abstrakt: Objective: To determine maternal omentin-1 levels and genetic variability in the omentin-1 gene in women with spontaneous term and preterm births (PTBs).Materials and Methods: Maternal serum omentin-1 levels and the role of the omentin-1 Val109Asp (rs2274907) polymorphism were evaluated in 32 women with spontaneous term birth (sTB) and 30 women with spontaneous preterm birth (sPTB) including women with (n = 16) and without (n = 14) preterm premature rupture of membranes (PPROM).Results: Maternal omentin-1 levels were significantly lower in women with sPTBs compared to term births during the hospitalization period (p = .015). However, maternal omentin-1 levels were similar in women with sPTBs with and without PPROM (p = .990). Furthermore, the omentin-1 Val109Asp polymorphism was found to have no significant effect on omentin-1 serum levels. In addition, no significant differences in genotype distributions and allelic frequencies between sTB and sPTB were established.Conclusions: High omentin-1 levels in normal sTBs compared to PTBs without significant differences between cases with and without PPROM suggest that omentin-1 plays a potential role in the pathophysiology of PTB but not in the PPROM mechanism itself. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index