| Autor: |
Kanakamedala, Madhava R., Giri, Shankar P. G., Hamilton, Robert D., Bhanat, Eldrin, Vijayakumar, Srinivasan |
| Předmět: |
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| Zdroj: |
Head & Neck; May2018, Vol. 40 Issue 5, p1034-1039, 6p |
| Abstrakt: |
Abstract: Background: The purpose of this study was to present the outcomes of oropharyngeal cancers treated with intensity‐modulated radiotherapy (IMRT) especially the differences between tonsillar and base of tongue (BOT) primaries. Methods: Retrospective analysis of 124 patients with biopsy proven squamous cell carcinomas of the oropharynx, treated with IMRT. Results: Human papillomavirus (HPV) association correlated with improvement in survivals in both tonsillar and BOT primaries. At the 2‐year median follow‐up, the cumulative incidences of locoregional recurrences were 8% in both the tonsil and BOT groups (P = .76) but the distant metastases were 8% in the tonsil group versus 26% in the BOT group (P = .009). Thirty percent of tonsil primaries has ≥N2c neck disease as compared to 54% of BOT. Incidence of distant metastases increases with advanced nodal classification, especially >N2c. Conclusion: Even though the locoregional controls are excellent with IMRT and chemotherapy, these patients continue to fail distantly, particularly significant for the BOT group and for nodal stage >N2c. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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