Geriatric nutritional risk index as a prognostic factor in patients with diffuse large B cell lymphoma.

Autor:	Kanemasa, Yusuke, Shimoyama, Tatsu, Sasaki, Yuki, Hishima, Tsunekazu, Omuro, Yasushi
Předmět:	ANTINEOPLASTIC agents MALNUTRITION diagnosis THERAPEUTIC use of monoclonal antibodies VINCRISTINE PREDNISONE CYCLOPHOSPHAMIDE MALNUTRITION AGE distribution GERIATRIC assessment ANTHROPOMETRY COMPARATIVE studies B cell lymphoma DOXORUBICIN LONGITUDINAL method RESEARCH methodology MEDICAL cooperation NUTRITIONAL assessment NUTRITIONAL requirements PROGNOSIS RESEARCH SURVIVAL analysis (Biometry) TUMOR classification URBAN hospitals EVALUATION research RELATIVE medical risk PROPORTIONAL hazards models RETROSPECTIVE studies DISEASE complications DIAGNOSIS THERAPEUTICS
Zdroj:	Annals of Hematology; Jun2018, Vol. 97 Issue 6, p999-1007, 9p
Abstrakt:	The geriatric nutritional risk index (GNRI) is a simple and well-established nutritional assessment tool that is a significant prognostic factor for various cancers. However, the role of the GNRI in predicting clinical outcomes of diffuse large B cell lymphoma (DLBCL) patients has not been investigated. To address this issue, we retrospectively analyzed a total of 476 patients with newly diagnosed de novo DLBCL. We defined the best cutoff value of the GNRI as 96.8 using a receiver operating characteristic curve. Patients with a GNRI < 96.8 had significantly lower overall survival (OS) and progression-free survival (PFS) than those with a GNRI ≥ 96.8 (5-year OS, 61.2 vs. 84.4%, P < 0.001; 5-year PFS, 53.7 vs. 75.8%, P < 0.001). Multivariate analysis showed that performance status, Ann Arbor stage, serum lactate dehydrogenase, and GNRI were independent prognostic factors for OS. Among patients with high-intermediate and high-risk by National Comprehensive Cancer Network-International Prognostic Index (NCCN-IPI), the 5-year OS was significantly lower in patients with a GNRI < 96.8 than in those with a GNRI ≥ 96.8 (high-intermediate risk, 59.5 vs. 75.2%, P = 0.006; high risk, 37.4 vs. 64.9%, P = 0.033). In the present study, we demonstrated that the GNRI was an independent prognostic factor in DLBCL patients. The GNRI could identify a population of poor-risk patients among those with high-intermediate and high-risk by NCCN-IPI. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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