Strategies for Modulation of Pharmacokinetics of Recombinant Therapeutic Proteins.

Autor: Zvonova, E. A., Tyurin, A. A., Soloviev, A. A., Goldenkova-Pavlova, I. V.
Zdroj: Biology Bulletin Reviews; Mar2018, Vol. 8 Issue 2, p124-141, 18p
Abstrakt: The review describes current approaches to the optimization of pharmacokinetic properties of pharmaceutical proteins in order to achieve the maximum therapeutic effect. Examples of such technologies, including PEGylation, PEG mimetics, glycosylation, protein-protein fusion, and their advantages and limitations are discussed. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index