Synthesis, Fungistatic, Protistocidal, and Antibacterial Activity of 1-(3-Amino-2-Hydroxypropyl)Indoles.

Autor: Suzdalev, K. F., Popov, L. D., Zubenko, A. A., Drobin, Yu. D., Fetisov, L. N., Bodryakov, A. N., Serbinovskaya, N. M.
Předmět:
Zdroj: Russian Journal of Bioorganic Chemistry; Mar2018, Vol. 44 Issue 2, p229-237, 9p
Abstrakt: A series of new indole derivatives containing the 3-amino-2-hydroxypropyl group at the nitrogen atom has been synthesized by the ring-opening of the oxirane cycle of 1-oxiranylmethylindoles. Their antibacterial, fungicidal, and protistocidal activities have been studied. Most of the synthesized compounds have been shown to exhibit a high protistocidal activity that several times exceeds that of the reference drug, baikoks (toltrazuril). [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index