| Autor: |
Paiella, Salvatore, Marchegiani, Giovanni, Miotto, Marco, Malpaga, Anna, Impellizzeri, Harmony, Montagnini, Greta, Pollini, Tommaso, Nessi, Chiara, Butturini, Giovanni, Capelli, Paola, Posenato, Ilaria, Scarpa, Aldo, D'Onofrio, Mirko, De Robertis, Riccardo, Cingarlini, Sara, Boninsegna, Letizia, Bassi, Claudio, Salvia, Roberto, Landoni, Luca |
| Předmět: |
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| Zdroj: |
Neuroendocrinology; Apr2018, Vol. 106 Issue 3, p234-241, 8p, 3 Charts, 1 Graph |
| Abstrakt: |
Introduction: Cystic pancreatic neuroendocrine tumors (CPanNETs) represent an uncommon variant of pancreatic neuroendocrine tumors (PanNETs). Due to their rarity, there is a lack of knowledge with regard to clinical features and postoperative outcome. Methods: The prospectively maintained surgical database of a high-volume institution was queried, and 46 resected CPanNETs were detected from 1988 to 2015. Clinical, demographic, and pathological features and survival outcomes of CPanNETs were described and matched with a population of 92 solid PanNETs (SPanNETs) for comparison. Results: CPanNETs accounted for 7.8% of the overall number of resected PanNETs (46/587). CPanNETs were mostly sporadic (n = 42, 91%) and nonfunctioning (39%). Two functioning CPanNETs were detected (4.3%), and they were 2 gastrinomas. The median tumor diameter was 30 mm (range 10-120). All tumors were well differentiated, with 38 (82.6%) G1 and 8 (17.4%) G2 tumors. Overall, no CPanNET showed a Ki-67 >5%. A correct preoperative diagnosis of a CPanNET was made in half of the cases. After a median follow-up of >70 months, the 5- and 10-year overall survival of resected CPanNETs was 93.8 and 62.5%, respectively, compared to 92.7 and 84.6% for SPanNETs (p > 0.05). The 5- and 10-year disease-free survival rates were 94.5 and 88.2% for CPanNETs and 81.8 and 78.9% for SPanNETs, respectively (p > 0.05). Conclusion: In the setting of a surgical cohort, CPanNETs are rare, nonfunctional, and well-differentiated neoplasms. After surgical resection, they share the excellent outcome of their well-differentiated solid counterparts for both survival and recurrence. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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