Implementation of evidence-based therapy in patients with systolic heart failure from 1998–2000.

Autor: Reibis, R., Dovifat, C., Dissmann, R., Ehrlich, B., Schulz, S., Stolze, K., Wegscheider, K., Völler, H.
Zdroj: Clinical Research in Cardiology; Mar2006, Vol. 95 Issue 3, p154-161, 8p
Abstrakt: Background In recent years, the incidence of systolic heart failure has increased. Besides a complete revascularization, guideline-based medication represents the most effective therapeutic approach. Aim Analysis of adherence of guideline-recommended and actual medication during inpatient cardiac rehabilitation as well as under subsequent outpatient conditions. Methods From 01/1998 to 12/ 2000, 1346 consecutive patients (64±10 years, 73% male, LVEF 36.3±8%, 88% ischemic, 6.7% valvular cardiomyopathy, 5.3% other causes, 11.8% atrial fibrillation) were included in a singlecenter prospective register. Medication was recorded at discharge and after the follow-up period of 731±215 days. Trends in prescription rates were analyzed based on nonparametric correlations (Spearman’s-Rho). Changes in medication from in- to outpatient settings were analyzed using exact McNemar test. Results At discharge 75.3% (67.9%/68.9%/ 86.6% in 1998/1999/2000, p<0.001) of the patients were treated as recommended. This rate dropped to 68.3% at followup (p<0.0001). Mortality within the follow-up period was low (12.6%). Conclusion It could be shown that from 1998 to 2000 inpatient guideline conformity was implementable adequately. Outpatient conformity was significantly lower. Although a high proportion of correctly prescribed CHF medication could be demonstrated, a further effort to improve guideline adherence in the management of heart failure patients is desirable. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index