| Abstrakt: |
Topical non-steroidal anti-inflammatory drugs (NSAIDs) are used for dilectoly treating specific sites of inflammation, thus avoiding adverse events (AEs) in the gastrointestinal tract and kidney resulting from oral administration. In recent years, large prescriptions of NSAIDs patches and leftover unused prescriptions have become a problem, and better control and use of prescribed patches has become an issue. The purpose of this study was to clarify the prescription volume of NSAIDs patches and the occurrence of AEs in fiscal year (FY) 2015. The targeted active ingredients of the survey were six components of the patches: ketoprofen, loxoprofen, flurbiprofen, felbinac, indomethacin and diclofenac. The prescription volume of NSAIDs patches was surveyed from the National Database of Health Insurance Claims and Specific Health Checkups of Japan (NDB) open data. AEs caused by topical NSAIDs were surveyed using the Japanese Adverse Drug Event Report database (JADER). The total prescription volume of NSAIDs patches was 4,820,224,437, and prescription for outpatients accounted for more than 99%. The prescription ratio of generic drugs for NSAIDs patches overall was 17.41%. The national average prescripton volume of NSAIDs patches was 37.9 per person. By prefecture, Akita had the highest prescription volume (56.3/person), and Kanagawa had the lowest (25.4/person). In FY 2015, 49,249 AE cases were registered in JADER. Among them, topical NSAIDs were the suspected drug in 34 cases, suggesting that the ratio of AEs for topical NSAIDs was very small. However, we found some serious systemic AEs. From this study, we were able to clarify the prescription situation for NSAIDs patches and the occurrence of associated AEs in FY 2015. We hope that these results will help to provide patients with an appropriate prescription volume and safe use ofNSAIDs patches. [ABSTRACT FROM AUTHOR] |
