A Stimuli-Responsive Supramolecular Hydrogel for Controlled Release of Drug.

Autor: Biswas, Subharanjan, Datta, Lakshmi Priya, Roy, Soumyajit
Předmět:
Zdroj: Journal of Molecular & Engineering Materials; Sep2017, Vol. 5 Issue 3, p-1, 13p
Abstrakt: An inexpensive, facile, and environmentally benign method has been developed for the preparation of stimuli-responsive and self-healing polyacrylic acid-chitosan-based supramolecular hydrogels. Guanidine hydrochloride is used as the supramolecular crosslinker to form an interconnected network with polyacrylic acid-chitosan complex. Because of the dynamic equilibrium between the hydrogen-bonding sites of the components, the hydrogels were found to be self-healable and sensitive to biochemical-stimulus, such as pH. Controlled loading of drug like doxorubicin and its significant anticancer activity of such hydrogels is worth mentioning. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index