A Convenient Synthetic Approach to Saccharin Derivatives Containing a Sulfonylamidine Scaffold.

Autor: Yantao Chen, Aurell, Carl-Johan, Korsgren, Pernilla, Malm, Johanna, Härslätt, Malin, Fridén-Saxin, Maria, Pettersen, Anna
Předmět:
Zdroj: Synthesis; 2018, Vol. 50 Issue 7, p1471-1481, 11p
Abstrakt: A key intermediate was obtained as solid through filtration of the reaction mixture of saccharin, chloro(triphenyl)phosphonium chloride, and N,N-diisopropylethylamine (DIPEA) in chloroform. The soluble triphenylphosphine oxide went to filtrate as waste, while the solid was reacted with amines to afford N-sulfonylamidines. In total, 26 N-sulfonylamidine products were obtained in moderate to good overall yields. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index