| Autor: |
Kostouros, George D., Olgart, Leif, Edwall, Lennart |
| Předmět: |
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| Zdroj: |
European Journal of Oral Sciences; Oct-Dec1996, Vol. 104 Issue 5/6, p577-582, 6p |
| Abstrakt: |
The blocking effect of lidocaine on nerve-induced vascular reactions was investigated in lower incisor teeth of anaesthetized rats. Pulpal blood flow was measured with laser Doppler flowmetry. Monopolar electrical stimulation of the rat incisor evoked a biphasic vascular response: an initial vasoconstriction was followed by a long-lasting vasodilation. Iontophoresis of lidocaine on a superficially exposed dentin surface with 60 μA of anodal direct current for 20 min blocked almost completely the stimulus-induced blood flow increase for about 25 min without any systemic effects. Iontophoresis of lidocaine with 40 μA for 20 min was almost without effect. Topical application of a mixture of lidocaine and prilocaine (25+25 mg/ml) in deep dentinal cavities was also without effect on the neurogenic reactions. Intravenous administration of lidocaine at 5 and 10 mg/ kg in rats pretreated with phenoxybenzamine reduced the stimulus-induced increase in blood flow by an average of 29% and 54%, respectively, whereas the remaining α-adrenoceptor resistant vasoconstriction was not influenced. The present results show that iontophoresis of lidocaine on exposed dentin blocks nerve-induced vascular responses without causing systemic effects. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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