| Autor: |
Agboola, Busola S., Ajala, Tolulope O., Odeku, Oluwatoyin A. |
| Předmět: |
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| Zdroj: |
Energy Technology; Mar2018, Vol. 6 Issue 3, p1-9, 9p |
| Abstrakt: |
The glidant property of starch obtained from the tubers of Cyperus esculentus, L is evaluated in comparison with purified talc and aerosil in metronidazole tablet formulation. C. esculentus starch is characterized using material, proximate, FTIR and rheological properties in comparison with corn starch BP. Metronidazole granules are prepared using wet granulation method, the granules are mixed with glidants (1-4% w/w) for 5 min and the flow characteristics determined. Tablets are compressed with a single punch machine at predetermined loads and evaluated using mechanical and release properties. The results shows that the proximate and material properties of C. esculentus are significantly different (p<0.05) from corn starch in fat content, particle size, carr's index, water absorption capacity and solubility. The FTIR revealed functional groups similar to that of corn starch while rheological profiles revealed that the starch will be able to withstand heat during tablet compression. The granules after the addition of glidants shows excellent flow according to Hausner ratio and Carr's index values. C. esculentus starch improved the flowabilty of granules used for the tablet formulations thus enhancing production process and outcome. The tablets with the highest balance of mechanical and release properties were those containing 2% w/w of C. esculentus starch and the difference is significantly higher in comparison to tablets containing other glidants. The results shows that C. esculentus starch could be suitable as a glidant in pharmaceutical tablet formulations. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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