| Autor: |
Sankoff, David, Chunfang Zheng, Baoyong Wang, Buen Abad Najar, Carlos Fernando |
| Předmět: |
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| Zdroj: |
BMC Bioinformatics; 2015 Suppl 17, Vol. 16, p1-7, 7p, 4 Graphs |
| Abstrakt: |
Background: The loss of duplicate genes - fractionation - after whole genome doubling (WGD) is the subject to a debate as to whether it proceeds gene by gene or through deletion of multi-gene chromosomal segments. Results: WGD produces two copies of every chromosome, namely two identical copies of a sequence of genes. We assume deletion events excise a geometrically distributed number of consecutive genes with mean μ ≥ 1, and these events can combine to produce single-copy runs of length l. If μ = 1, the process is gene-by-gene. If μ > 1, the process at least occasionally excises more than one gene at a time. In the latter case if deletions overlap, the later one simply extends the existing run of single-copy genes. We explore aspects of the predicted distribution of the lengths of single-copy regions analytically, but resort to simulations to show how observing run lengths l allows us to discriminate between the two hypotheses. Conclusions: Deletion run length distributions can discriminate between gene-by-gene fractionation and deletion of segments of geometrically distributed length, even if μ is only slightly larger than 1, as long as the genome is large enough and fractionation has not proceeded too far towards completion. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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