| Autor: |
Haberland‐Carrodeguas, Christel, Allen, Carl M., Beck, F. Michael, Buesching, William J., Koletar, Susan L., Sundstrom, Paula |
| Předmět: |
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| Zdroj: |
Journal of Oral Pathology & Medicine; Feb2002, Vol. 31 Issue 2, p99-105, 7p, 2 Charts |
| Abstrakt: |
Background: In contrast to the immunosupressed patient population, the prevalence of fluconazole-resistant strains of Candida albicans among healthy individuals has not been extensively studied. Methods: Candida species were cultured from 50 healthy out-patients with clinical signs of oral candidiasis. Following one week of the recommended fluconazole regimen, post-treatment cultures were obtained. Both pre- and post-treatment yeasts were identified and in vitro susceptibility testing was performed using the NCCLS M-27A method. Strains were further differentiated using established eDNA probes. Results: Forty-tour patients (88%) had positive C. albicans cultures prior to treatment. Antifungal susceptibility testing of these strains demonstrated no in vitro resistance to fluconazole. At post-treatment evaluation, eight patients (18%) had persistent signs of infection and 10 patients (23%) had positive Candida sp. cultures despite no clinical signs of infection. DNA analysis confirmed that the same C.albicans strain was present both in the pre-treatment and the post-treatment cultures. Conclusions: Our results showed that the presence of fluconazole-resistant strains of C.albicans does not appear to be prevalent among healthy outpatients furthermore, in vitro antifungal susceptibility testing does not always predict successful therapy in these patients. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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