| Autor: |
Hao-ting Zhu, Yang He, Li Zhan, Ting Liu, Shi-qiong Yang, Li-tao Kang, Yu Luo |
| Předmět: |
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| Zdroj: |
Journal of Chemical Research; Feb2018, Vol. 42 Issue 2, p105-108, 4p |
| Abstrakt: |
A practical eight-step synthesis of a key intermediate of beraprost is described. The tricyclic cyclopent[b]benzofuran core can be prepared from 2,6-dibromo-4-chlorophenol. The butyric side chain is introduced by ortho-selective metal–halogen exchange and subsequent coupling with 4-(benzyloxy)butanal. The procedure is operationally simple and amenable to scale-up synthesis. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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